1) Decoding immune profiles OR Immune profiling
Immunoglobulins (B cell receptors) and T cell receptors are crucial factors of immune response against pathogens. We examine various receptors characteristics regarding mainly diversity, reactivity, sequence and structural patterns using low and, recently developed, high throughput sequencing technologies in different scenarios ranging from leukemia to allergy.
2) Investigating the tumor-microenvironment crosstalk
The tumor microenvironment is the cellular environment in which the tumor exists, and includes immune cells, surrounding blood vessels, and other soluble factors. The tumor and the surrounding microenvironment are closely related and interact constantly through receptors which bind to different substances. We study the immune receptors activation, which contributes to tumor heterogeneity by triggering a biochemical chain of events inside the cell, eventually affecting tumor cell fate.
3) Cancer Genomics and Epigenomics
A genome is an organism’s complete set of DNA. Each genome encompasses all the information needed to build and maintain that organism. Genes, the basic unit of the genome, are often called the blueprint for life because they tell each of your cells what to do and when to do it.
Epigenomics literally means “on top of” genomics. It refers to external modifications to DNA that turn genes “on” or “off.” These modifications do not change the DNA sequence, but instead, they affect how cells “read” genes. If DNA is the “hardware”, epigenetics is the “software”.
It is well known that alterations at both these levels play a central role in cancer development. We study the genomic and epigenomic profiles of patients with lymphoid malignancies in order to dissect the underlying mechanisms.
4) Mechanisms of neurodegeneration
Neurodegenerative diseases are caused by misfolded proteins that lose their normal conformation and subsequently, their function. Despite the fact that several mutations are related to protein misfolding, in most cases the exact pathogenic mechanisms remain largely unknown. Here, we attempt to unravel these mechanisms using genetic or biochemical assays in disease cell models.
5) Handling systems for Clinicobiological data
6) Clinical epidemiology
7) Biostatistics & Bioinformatics